Adam’s paper on the design of microgels as in situ forming implant (ISFI) for sustained drug delivery has been published in Nanoscale. In this work, he developed dual-responsive microgels that would form well-defined aggregated when exposed to physiological temperature and ionic strength, avoiding any potential issues with aggregate formation in the needle. We found that the microgels could entrap up to 40 wt % of dug payload nanoparticles, offered tunable drug release exceeding 120 days and were not cytotoxic in vitro.
The Nanomedicine Team at Liverpool was awarded “Partnership of the Year” at the university’s annual staff awards.
Our long standing collaboration with the Nanomedicine Team at Liverpool has resulted in an article recently published in Nature Communications. In this paper, we highly an acceleration approach to the discover of HIV nanomedicines. We used a rapid small-scale screening method to produce large libraries of solid drug nanoparticles targeting oral dose. Through a close integration with pharmacology, we carried out iterative pharmacological and chemical evaluation to establish potential candidates for progression through to clinical manufacture. The wide applicability of our strategy has implications for multiple therapy development programmes.
See here for the full article.
After the successful first British Society for Nanomedicine (BSNM) Early Career Researchers Meeting (ECRM) at Liverpool in 2015, Edyta and Adam were excited to attend the BSNM ECRM 2016 in Swansea. Adam presented an oral presentation on nanogel-nanoparticle composites for drug delivery, and Edyta presented a poster presentation on novel characterisation techniques to enable nanomedicine design, including asymmetrical field-flow field fractionation. A wide variety of work was presented covering Physics, Chemistry, Materials Science and Pharmacology, representing the multidisciplinary nature of Nanomedicine. Of particular interest was the work from Pharmacologists, which demonstrated how a variety of nanomedicines move through various stages of biological testing, which will help inform us on the initial design of materials in our lab. Another highlight was the poster session, breakfast was provided in the poster room, to encourage engagement between delegates, and judges made an effort to make sure every poster presenter got a chance to present their work in depth.
Adam attended the WBC conference in Montreal to give an oral presentation of the work on his work on nanogel/solid drug nanoparticle composites for sustained drug delivery. This was Adam’s first oral conference presentation and first conference in North America. He particularly liked the fact that the conference had been designed to provide lots of social activities and networking opportunities, particularly for students. Social activities included a treasure hunt around Montreal after the opening reception, in order for students to get to know each other and find out about each other’s research. There were also many networking opportunities such as a pancake breakfast with top researchers in the field, and lunch and learns with smaller focused groups.
Adam was awarded a DH Richards Bursary enabling him to travel and present his work at the 2015 European Polymer Congress in Dresden, Germany. This was Adam’s first opportunity to attend a conference outside the UK, something and he enjoyed and found really useful. We’d like to thank the Marco Group UK for this financial support, please click here to see Adam’s summary of the conference.
Congratulations to Quanling on receiving the Gold CREST award for her Nuffield Foundation summer project.